National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10489

Target Organs and Levels of Evidence for TR-420

Toxicology and Carcinogenesis Studies of Triamterene (CASRN 396-01-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Triamterene
396-01-0
11/21/1991Diuretic and natriuretic agent. Dosed-Feed
R: 0,150,300,600, M: 0,100,200,400 PPM RESTART MICE: 0,400 PPM/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 6/50 4/50 3/49
Non-Neoplastic Lesions
  • LIVER: HYPERPLASIA; EOSINOPHILIC FOCI; MIXED CELL FOCI; INCREASED SEVERITY OF NEPHROPATHY
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CLEAR CELL FOCI; MIXED CELL FOCI; INCREASED SEVERITY OF NEPHROPATHY
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (FIRST STUDY) ADENOMA 17/50 22/50 19/50 20/60 OR CARCINOMA 5/50 7/50 3/50 13/60 COMBINED 20/50 26/50 19/50 29/60; (SECOND STUDY) ADENOMA 21/50 36/50 OR CARCINOMA 9/50 11/50 COMBINED 25/50 38/50
Non-Neoplastic Lesions
  • THYROID GLAND: (FIRST STUDY) FOLLICULAR CELL HYPERPLASIA; (SECOND STUDY) FOLLICULAR CELL HYPERPLASIA
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (FIRST STUDY) ADENOMA 10/50 22/50 23/50 36/60 OR CARCINOMA 4/50 4/50 3/50 8/60 COMBINED 13/50 26/50 25/50 37/60; (SECOND STUDY) ADENOMA 7/50 28/51 OR CARCINOMA 5/50 11/51 COMBINED 10/50 31/51
Non-Neoplastic Lesions
  • LIVER: (FIRST STUDY) BASOPHILIC FOCI, CLEAR CELL FOCI; (SECOND STUDY) BASOPHILIC FOCI, CLEAR CELL FOCI
  • THYROID GLAND: (FIRST STUDY) FOLLICULAR CELL HYPERPLASIA; (SECOND STUDY) FOLLICULAR CELL HYPERPLASIA


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