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Target Organs and Levels of Evidence for TR-430

Toxicology and Carcinogenesis Studies of C.I. Direct Blue 218 (CASRN 28407-37-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
C.I. Direct blue 218
28407-37-6
Dye for cellulose, acetate, nylon, silk, wool, tissue and fine papers. Dosed-Feed
0,3000,20000 PPM/10 PER GROUP
International Research & Development Corp.

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
C.I. Direct blue 218
28407-37-6
12/01/1992Dye for cellulose, acetate, nylon, silk, wool, tissue and fine papers. Dosed-Feed
R&M: 0, 1000, 3000, 10000 PPM/60 PER GROUP
BioReliance, Inc

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Oral Cavity: SQUAMOUS CELL PAPILLOMA 0/50 0/50 0/50 5/51; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 1/51; BASOSQUAMOUS TUMOR BENIGN 0/50 0/50 0/50 1/51
May Have Been Related
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 0/50
Non-Neoplastic Lesions
  • FORESTOMACH: BASAL CELL HYPERPLASIA
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: BASAL CELL HYPERPLASIA
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 16/50 19/50 17/50 40/50; CARCINOMA 7/50 3/50 8/50 17/50
May Have Been Related
  • Kidney Tubular Cell: ADENOMA 0/50 2/50 1/50 1/50 OR CARCINOMA 0/50 1/50 0/50 0/50 COMBINED 0/50 3/50 1/50 1/50
  • Intestines: CARCINOMA 1/50 0/50 0/50 3/50
Non-Neoplastic Lesions
  • LIVER: BASOPHILIC FOCI; EOSINOPHILIC FOCI
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 7/49 12/50 17/49 41/49; CARCINOMA 5/49 5/50 6/49 12/49
Non-Neoplastic Lesions
  • LIVER: BASOPHILIC FOCI; CLEAR CELL FOCI; EOSINOPHILIC FOCI