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Target Organs and Levels of Evidence for TR-431

Toxicology and Carcinogenesis Studies of Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1 Mice Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Benzyl acetate
140-11-4
12/01/1992Soap fragrance; flavoring ingredient; solvent for cellulose acetate and cellulose nitrate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. And as a component of printing inks and varnish removers.Dosed-Feed
R: 0,0.3,0.6,1.2%, M: 0,0.033,0.1,0.3%/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM, ATROPHY AND DEGENERATION; GLANDS, CYSTIC HYPERPLASIA; MUCOSA, EXUDATE AND PIGMENTATION
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM, ATROPHY AND DEGENERATION; GLANDS, CYSTIC HYPERPLASIA; MUCOSA, EXUDATE AND PIGMENTATION