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Target Organs and Levels of Evidence for TR-433

Toxicology and Carcinogenesis Studies of Tricresyl Phosphate (CASRN 1330-78-5) in F344/N Rats and B6C3F1 Mice (Gavage and Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Tricresyl phosphate
1330-78-5
06/22/1993Plasticizer, fire retardant for plastics, heat exchange & air filter medium, waterproofing, hydraulic fluid, lead scavenger in gasoline (Merck 1989). Tricresyl phosphate is an organophosphate plasticizer widely used in vinyl plastics and as a fire retardant additive for hydraulic fluids.Dosed-Feed
R: 0,75,150,300,600, M: 0,60,125,250 PPM/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • ADRENAL GLAND: CYTOPLASMIC VACUOLIZATION
  • OVARY: INTERSTITIAL HYPERPLASIA
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • ADRENAL: CEROID PIGMENTATION
  • LIVER: CEROID PIGMENTATION; CLEAR CELL FOCI; FATTY CHANGE
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • ADRENAL: CEROID PIGMENTATION