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https://ntp.niehs.nih.gov/go/8654

Target Organs and Levels of Evidence for TR-438

Toxicology and Carcinogenesis Studies of Benzethonium Chloride (CASRN 121-54-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Benzethonium chloride
121-54-0
Used primarily in cosmetics for its antimicrobial and cationic surfactant properties. Topical anti-infective (vet) and antiseptic. Germicide for cleansing food and dairy utensils. In controlling swimming pool algae and dandruff.Topical Application
0,1.56,25.0 MG/KG/10 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Benzethonium chloride
121-54-0
06/21/1994Used primarily in cosmetics for its antimicrobial and cationic surfactant properties. Topical anti-infective (vet) and antiseptic. Germicide for cleansing food and dairy utensils. In controlling swimming pool algae and dandruff.Topical Application
R&M: 0,0.15,0.5,1.5 MG/KG/50/GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPITHELIAL HYPERPLASIA
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPITHELIAL HYPERPLASIA; SEBACEOUS GLAND HYPERPLASIA; ULCER
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPITHELIAL HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPITHELIAL HYPERPLASIA