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Target Organs and Levels of Evidence for TR-445

Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CASRN 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Scopolamine hydrobromide trihydrate
6533-68-2
Anticholinergic -- used in ophthalmic preparations and as a preanesthetic sedative. Its major use is in transdermal patches for the treatment of motion sickness.Gavage
0,15,1200 MG/KG/10 PER GROUP
Southern Research Institute

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Scopolamine hydrobromide trihydrate
6533-68-2
06/20/1995Anticholinergic -- used in ophthalmic preparations and as a preanesthetic sedative. Its major use is in transdermal patches for the treatment of motion sickness.Gavage
R&M: 0,1,5, OR 25 MG/KG; 70/GROUP DIET RESTRICTION MICE: 0 OR 25 MG/KG;70/GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: No Evidence
 Mice: No Evidence