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Target Organs and Levels of Evidence for TR-446

Toxicology and Carcinogenesis Studies of 1-Trans-Delta9-Tetrahydrocannabinol (CASRN 1972-08-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1-trans-delta-9-Tetrahydrocannabinol
1972-08-3
Topical use in hypertensive glaucomas. Active constituent of marijuana. Gavage
0, 5, OR 500 MG/KG/10 PER GROUP
SRI International

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1-trans-delta-9-Tetrahydrocannabinol
1972-08-3
06/21/1994Topical use in hypertensive glaucomas. Active constituent of marijuana. Gavage
R: 0, 12.5, 25, OR 50; M: 0, 125, 250, OR 500 MG/KG; 50/GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Other Considerations
  • PITUITARY GLAND: ADENOMA 21/52 19/51 14/51 9/52
  • PANCREAS: ADENOMA 8/52 0/51 2/52 0/52
  • TESTIS: INTERSTITIAL CELL ADENOMA 46/52 40/51 36/52 43/52
Female Rats: No Evidence
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 0/62 6/60 3/61 1/57
Non-Neoplastic Lesions
  • FORESTOMACH: HYPERPLASIA; ULCER
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Other Considerations
  • LIVER: ADENOMA 25/62 11/60 6/61 2/57 OR CARCINOMA 10/62 3/60 5/61 1/57 COMBINED 31/62 13/60 9/61 3/57; EOSINOPHILIC FOCI 18/62 1/60 0/61 0/57; FATTY CHANGE 20/62 11/60 1/61 1/57
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA 4/60 9/60 3/60 1/60
Non-Neoplastic Lesions
  • THYROID GLAND: FOLLICULAR CELL HYPERPLASIA
Other Considerations
  • LIVER: ADENOMA 17/60 9/60 7/59 3/60 OR CARCINOMA 6/60 5/60 4/59 1/60 COMBINED 22/60 14/60 11/59 4/60; EOSINOPHILIC FOCI 9/60 0/60 1/59 1/60; FATTY CHANGE 13/60 3/60 0/59 2/60