https://ntp.niehs.nih.gov/go/8680

Target Organs and Levels of Evidence for TR-451

Toxicology and Carcinogenesis Studies of Nickel Oxide (CASRN 1313-99-1) in F344 Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Nickel (II) oxide
1313-99-1		 11/29/1994 Inhalation
R: 0, .62, 1.25, OR 2.5 M: 0, 1.25, 2.5, OR 5.0 MG/M3; 50/GROUP		 Lovelace Biomedical & Environmental Research Institute

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/54 1/53 3/53 2/52 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/54 0/53 3/53 2/52 OR SQUAMOUS CELL CARCINOMA 1/54 0/53 0/53 0/52 COMBINED 1/54 1/53 6/53 4/52
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 27/54 24/52 26/53 32/52 OR MALIGNANT PHEOCHROMOCYTOMA 0/54 0/52 1/53 6/52 COMBINED 27/54 24/52 27/53 35/52
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION; PIGMENT
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; PIGMENT
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/53 0/53 1/53 4/54 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 0/53 5/53 1/54 COMBINED 1/53 0/53 6/53 5/54
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 4/51 7/52 6/53 18/53
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION; PIGMENT
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; PIGMENT
  • ADRENAL GLAND: (MEDULLA) HYPERPLASIA
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION; PIGMENT
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; PIGMENT
Female Mice: Equivocal Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 2/64 4/66 10/63 3/64 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 4/64 11/66 4/63 5/64 COMBINED 6/64 15/66 12/63 8/64
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION; PIGMENT
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; PIGMENT