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Target Organs and Levels of Evidence for TR-453

Toxicology and Carcinogenesis Studies of Nickel Subsulfide (CASRN 12035-72-2) in F344 Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Nickel subsulfide
12035-72-2
11/29/1994Major component in nickel refinery flue dust. Not used commercially in U.S.Inhalation
R: 0, 0.075, OR 0.15 M: 0, 0.6, OR 1.2 MG/M3; 50/GROUP
Lovelace Biomedical & Environmental Research Institute

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR ADENOMA OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 6/53 11/53
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 13/53 30/52 38/53 OR MALIGNANT PHEOCHROMOCYTOMA 0/53 2/52 10/53 COMBINED 14/53 30/52 38/53
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; FOCAL ALVEOLAR EPITHELIAL HYPERPLASIA; MACROPHAGE HYPERPLASIA; FIBROSIS
  • NASAL CAVITY: CHRONIC ACTIVE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 2/53 5/53 5/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53 OR SQUAMOUS CELL CARCINOMA 0/53 1/53 0/53 COMBINED 2/53 6/53 9/53
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 2/53 7/53 36/53
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; FOCAL ALVEOLAR EPITHELIAL HYPERPLASIA; MACROPHAGE HYPERPLASIA; FIBROSIS
  • NASAL CAVITY: CHRONIC ACTIVE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY
  • ADRENAL GLAND: (MEDULLA) HYPERPLASIA
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; FIBROSIS
  • NASAL CAVITY: ACUTE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; FIBROSIS
  • NASAL CAVITY: ACUTE INFLAMMATION; OLFACTORY EPITHELIAL ATROPHY