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Target Organs and Levels of Evidence for TR-454

Toxicology and Carcinogenesis Studies of Nickel Sulfate Hexahydrate (CASRN 10101-97-0) in F344 Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Nickel sulfate hexahydrate
10101-97-0
11/29/1994Nickel plating. Blackening zinc and brass. Mordant in dyeing and printing textiles. Manufacture of organic nickel salts.Inhalation
R: 0, 0.125, 0.25, OR 0.5 M: 0, .25, .5, OR 1.0 MG/M3; 50/GROUP
Lovelace Biomedical & Environmental Research Institute

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; MACROPHAGE HYPERPLASIA; ALVEOLAR PROTEINOSIS; FIBROSIS
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; MACROPHAGE HYPERPLASIA; ALVEOLAR PROTEINOSIS; FIBROSIS
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; INTERSTITIAL INFILTRATION; ALVEOLAR PROTEINOSIS
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; MACROPHAGE HYPERPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC ACTIVE INFLAMMATION; BRONCHIALIZATION; MACROPHAGE HYPERPLASIA; INTERSTITIAL INFILTRATION; ALVEOLAR PROTEINOSIS
  • LYMPH NODE: (BRONCHIAL) LYMPHOID HYPERPLASIA; MACROPHAGE HYPERPLASIA
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY