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Target Organs and Levels of Evidence for TR-461

Toxicology and Carcinogenesis Studies of Nitromethane (CASRN 75-52-5) in F344 Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Nitromethane
75-52-5
12/05/1995Fuel additive and propellant; synthesis intermediate for agricultural fumigants, intermediate for nitro and amino alcohols, biocides, and other products; cellulosic compound solvent; explosive in mining, oil-well drilling, and seismic exploration. Detected in air, surface and drinking water, and in cigarette smoke. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R: 0, 94, 188, OR 375 PPM; 50/GROUP M: 0, 188, 375, OR 750 PPM; 50/GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: FIBROADENOMA 19/50 21/50 33/50 36/50 OR CARCINOMA 2/50 7/50 1/50 11/50 COMBINED 9/50 25/50 34/50 39/50
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: ADENOMA 9/50 10/50 19/50 32/50 OR CARCINOMA 1/50 1/50 6/50 5/50 COMBINED 10/50 11/50 25/50 37/50
  • Lung: ALVEOLAR ADENOMA 11/50 10/50 9/50 12/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 3/50 3/50 11/50 COMBINED 13/50 13/50 12/50 20/50
Non-Neoplastic Lesions
  • NOSE: OLFACTORY EPITHELIUM, DEGENERATION; OLFACTORY EPITHELIUM, METAPLASIA; RESPIRATORY EPITHELIUM, HYALINE DEGENERATION
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Harderian Gland: ADENOMA 5/50 7/50 16/50 19/50 OR CARCINOMA 1/50 2/50 4/50 3/50 COMBINED 6/50 9/50 20/50 21/50
  • Liver: ADENOMA 14/50 25/50 17/50 35/50 OR CARCINOMA 10/50 14/50 8/50 12/50 COMBINED 19/50 34/50 22/50 40/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/50 2/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/50 5/50 3/50 COMBINED 3/50 6/50 6/50 12/50
Non-Neoplastic Lesions
  • NOSE: OLFACTORY EPITHELIUM, DEGENERATION; OLFACTORY EPITHELIUM, METAPLASIA; RESPIRATORY EPITHELIUM, HYALINE DEGENERATION