National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6239

Target Organs and Levels of Evidence for TR-464

Toxicology and Carcinogenesis Studies of Technical Grade Sodium Xylene Sulfonate (CASRN 1300-72-7) in F344 Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Sodium xylenesulfonate
1300-72-7
Hydrotrope in liquid detergents, shampoos, degreasing compounds. Used in textile, paper, and leather industries. Topical Application
R&M: 120.0,39.9,13.2,4.5,1.5,0 MG/KG
Southern Research Institute

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Sodium xylenesulfonate
1300-72-7
12/05/1995Hydrotrope in liquid detergents, shampoos, degreasing compounds. Used in textile, paper, and leather industries. Topical Application
R: 0, 60, 120, OR 240 MG/KG M: 0, 182, 364, OR 727 MG/KG (50/SEX/GROUP)
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Skin: EPIDERMAL HYPERPLASIA 1/50 0/50 4/50 5/50
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Skin: EPIDERMAL HYPERPLASIA 1/50 0/50 4/50 5/50
Female Mice: No Evidence


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