National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6247

Target Organs and Levels of Evidence for TR-468

Toxicology and Carcinogenesis Studies of Oxazepam (CASRN 604-75-1) in F344/N Rats (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Oxazepam
604-75-1
12/11/1996Tranquilizer -- used therapeutically as a sedative-hypnotic and antianxiety agent.Dosed-Feed
0, 625, 1250, 2500, 5000, OR 10000 PPM; 50/SEX/GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 1/50 0/50 3/50 1/50 (SINGLE AND STEP SECTIONS) 2/50 1/50 7/50 6/50; (STOP STUDY) SINGLE SECTIONS 0/50, SINGLE AND STEP SECTIONS 6/45
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
  • FORESTOMACH: CHRONIC INFLAMMATION; ULCER; EPITHELIAL HYPERPLASIA
  • GLANDULAR STOMACH: MINERALIZATION
  • INTESTINES: DUODENUM, EROSION
  • LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
  • FORESTOMACH: CHRONIC INFLAMMATION; ULCER; EPITHELIAL HYPERPLASIA
  • GLANDULAR STOMACH: EROSION
  • LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY


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