Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/6247

Oxazepam: Target Organs and Levels of Evidence for TR-468

Toxicology and Carcinogenesis Studies of Oxazepam (CASRN 604-75-1) in F344/N Rats (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Oxazepam
604-75-1
12/11/1996Tranquilizer -- used therapeutically as a sedative-hypnotic and antianxiety agent.Dosed-Feed
0, 625, 1250, 2500, 5000, OR 10000 PPM; 50/SEX/GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: (SINGLE SECTIONS) ADENOMA 1/50 0/50 3/50 1/50 (SINGLE AND STEP SECTIONS) 2/50 1/50 7/50 6/50; (STOP STUDY) SINGLE SECTIONS 0/50, SINGLE AND STEP SECTIONS 6/45
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
  • FORESTOMACH: CHRONIC INFLAMMATION; ULCER; EPITHELIAL HYPERPLASIA
  • GLANDULAR STOMACH: MINERALIZATION
  • INTESTINES: DUODENUM, EROSION
  • LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
  • FORESTOMACH: CHRONIC INFLAMMATION; ULCER; EPITHELIAL HYPERPLASIA
  • GLANDULAR STOMACH: EROSION
  • LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY