https://ntp.niehs.nih.gov/go/6247
Target Organs and Levels of Evidence for TR-468
Toxicology and Carcinogenesis Studies of Oxazepam (CASRN 604-75-1) in F344/N Rats (Feed Studies)
Chemical (Study Title)
CASRN | Peer Review Date | Primary Uses | Route/Exposure Levels | Study Laboratory |
|---|
Oxazepam
604-75-1 | 12/11/1996 | Tranquilizer -- used therapeutically as a sedative-hypnotic and antianxiety agent. | Dosed-Feed
0, 625, 1250, 2500, 5000, OR 10000 PPM; 50/SEX/GROUP | Battelle Columbus Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Neoplastic Lesions | - Kidney Tubular Cell:
(SINGLE SECTIONS) ADENOMA 1/50 0/50 3/50 1/50 (SINGLE AND STEP SECTIONS) 2/50 1/50 7/50 6/50; (STOP STUDY) SINGLE SECTIONS 0/50, SINGLE AND STEP SECTIONS 6/45
|
| Non-Neoplastic Lesions | - KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
- FORESTOMACH: CHRONIC INFLAMMATION; ULCER; EPITHELIAL HYPERPLASIA
- GLANDULAR STOMACH: MINERALIZATION
- INTESTINES: DUODENUM, EROSION
- LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY
|
Female Rats: No Evidence
| Type | Organ/Tissue (Lesion) |
|---|
| Non-Neoplastic Lesions | - KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
- FORESTOMACH: CHRONIC INFLAMMATION; ULCER; EPITHELIAL HYPERPLASIA
- GLANDULAR STOMACH: EROSION
- LIVER: HEPATOCYTE CENTRILOBULAR HYPERTROPHY
|
