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Target Organs and Levels of Evidence for TR-469

Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
3'-Azido-3'-deoxythymidine (AIDS)
30516-87-1
12/11/1996Pyrimidine nucleoside analog with antiviral activity used in the treatment of AIDS (Merck 1989)Gavage
MICE ONLY: 0, 30, 60, OR 120 MG/KG; 50/SEX
Southern Research Institute

Levels of Evidence

Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/48 0/49 3/50 OR CARCINOMA 0/50 0/48 0/49 1/50 COMBINED 0/50 0/48 0/49 4/50
  • Harderian Gland: ADENOMA 3/33 2/50 2/50 10/46 OR CARCINOMA 0/33 3/50 2/50 0/46 COMBINED 3/33 5/50 2/50 10/46
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vagina: SQUAMOUS CELL CARCINOMA 0/50 0/50 5/50 9/50; SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 5/50 11/50
Non-Neoplastic Lesions
  • Vagina: EPITHELIAL HYPERPLASIA


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Interferon AD (AIDS Initiative)
INTERFERONAD
12/11/1996Experimental AIDS therapySubcutaneous Injection
MICE ONLY: 500 OR 5000 UNITS 3X/WEEK; 50/SEX/GROUP
Southern Research Institute

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative)
INTAZTCOMB
12/11/1996Used in the experimental treatment of AIDSSubcutaneous Injection and Gavage
DUAL ROUTES WITH BOTH COMPOUNDS: AZT: 0, 30, 60, OR 120 (GAV) MG/KG; IFN: 500 OR 5000 UNITS 3X/WEEK
Southern Research Institute

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Interferon A (AIDS Initiative)
76543-88-9
12/11/1996Experimental AIDS therapy, antiviral drug, antineoplastic agentSubcutaneous Injection
5000 UNITS 3X A WEEK; 50/SEX/GROUP
Southern Research Institute

Levels of Evidence