https://ntp.niehs.nih.gov/go/6253

Target Organs and Levels of Evidence for TR-471

Toxicology and Carcinogenesis Studies of Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Cobalt sulfate heptahydrate
10026-24-1		 12/11/1996 Inhalation
R&M: 0, 0.3, 1.0, OR 3.0 MG/M3; 50/SEX/SPECIES/GROUP		 Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 1/48 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/50 3/48 1/50 COMBINED 1/50 4/50 4/48 7/50
May Have Been Related
  • Adrenal Gland Medulla: BENIGN PHEOCHROMOCYTOMA 14/50 19/50 23/49 20/50, MALIGNANT PHEOCHROMOCYTOMA 0/50 2/50 2/49 2/50, OR COMPLEX PHEOCHROMOCYTOMA 1/50 0/50 1/49 0/50 COMBINED 15/50 19/50 25/49 20/50
Non-Neoplastic Lesions
  • LUNG: EPITHELIAL HYPERPLASIA; EPITHELIAL METAPLASIA; GRANULOMATOUS ALVEOLAR INFLAMMATION; INTERSTITIAL FIBROSIS; PROTEINOSIS
  • NASAL CAVITY: LATERAL WALL HYPERPLASIA; LATERAL WALL SQUAMOUS METAPLASIA; OLFACTORY EPITHELIAL ATROPHY; OLFACTORY EPITHELIAL METAPLASIA
  • LARYNX: EPIGLOTTIS SQUAMOUS METAPLASIA
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/49 10/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 6/50 6/50 COMBINED 0/50 3/49 16/50 16/50
  • Adrenal Gland Medulla: BENIGN PHEOCHROMOCYTOMA 2/48 1/49 3/50 8/48, MALIGNANT PHEOCHROMOCYTOMA 0/48 0/49 1/50 1/48 OR COMPLEX PHEOCHROMOCYTOMA 0/48 0/49 0/50 1/48 COMBINED 2/48 1/49 4/50 10/48
Non-Neoplastic Lesions
  • LUNG: EPITHELIAL HYPERPLASIA; SQUAMOUS METAPLASIA; EPITHELIAL METAPLASIA; GRANULOMATOUS ALVEOLAR INFLAMMATION; INTERSTITIAL FIBROSIS; PROTEINOSIS
  • NASAL CAVITY: LATERAL WALL HYPERPLASIA; LATERAL WALL SQUAMOUS METAPLASIA; OLFACTORY EPITHELIAL ATROPHY; OLFACTORY EPITHELIAL METAPLASIA
  • LARYNX: EPIGLOTTIS SQUAMOUS METAPLASIA
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 9/50 12/50 13/50 18/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 4/50 5/50 7/50 11/50 COMBINED 11/50 14/50 19/50 28/50
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY; OLFACTORY EPITHELIAL HYPERPLASIA
  • LARYNX: SQUAMOUS METAPLASIA
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 6/50 9/50 10/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 1/50 4/50 9/50 COMBINED 4/50 7/50 13/50 18/50
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIAL ATROPHY; OLFACTORY EPITHELIAL HYPERPLASIA
  • LARYNX: SQUAMOUS METAPLASIA