National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6255

Target Organs and Levels of Evidence for TR-472

Toxicology and Carcinogenesis Studies of Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Isobutyraldehyde
78-84-2
Synthesis of pantothenic acid, cellulose esters, perfumes, flavors, and gasoline additives. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
0,500,8000 PPM/10 PER GROUP
Hazleton Labs, Rockville, Goverment Services, Inc

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Isobutyraldehyde
78-84-2
12/12/1996Synthesis of pantothenic acid, cellulose esters, perfumes, flavors, and gasoline additives. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R&M: 0, 500, 1000, OR 2000 PPM (50/SEX/SPECIES/GROUP)
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; OLFACTORY EPITHELIUM DEGENERATION; SUPPURATIVE INFLAMMATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; OLFACTORY EPITHELIUM DEGENERATION; SUPPURATIVE INFLAMMATION
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM DEGENERATION
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: OLFACTORY EPITHELIUM DEGENERATION


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