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https://ntp.niehs.nih.gov/go/10201

Target Organs and Levels of Evidence for TR-475

Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Tetrahydrofuran
109-99-9
12/11/1996Reaction medium for grignard and metal hydride reactions. Packaging fabrication. Solvent for resins and plastics. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R&M: 0, 200, 600, OR 1800 PPM (50/SEX/SPECIES/GROUP)
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 1/50 1/50 4/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 1/50 1/50 4/50 5/50
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 12/50 17/50 18/50 31/48 OR CARCINOMA 6/50 10/50 10/50 16/48 COMBINED 17/50 24/50 26/50 41/48


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Tetrahydrofuran
109-99-9
Reaction medium for grignard and metal hydride reactions. Packaging fabrication. Solvent for resins and plastics. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R&M: 0,66,200,600,1800,5000 PPM
Battelle Northwest Laboratory

Levels of Evidence