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Target Organs and Levels of Evidence for TR-483

Toxicology and Carcinogenesis Studies of Pentachlorophenol (CASRN 87-86-5) in F344/N Rats (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Pentachlorophenol, purified
87-86-5
12/10/1997Wood preservative, fungicide, soil fumigant for termites, preharvest defoliant, seed treatment for beans, preservative for paint, leather, textiles, inks, antibacterial agent in disinfectants & cleansers (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0, 200, 400, OR 600 PPM; 50/SEX/GROUP - 1000 PPM STOP STUDY (60/SEX)
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): MESOTHELIOMA 1/50 0/50 2/50 0/50 9/50 (STOP STUDY)
  • Nasal Cavity: CARCINOMA 1/50 3/50 1/50 0/50 5/50 (STOP STUDY)
Other Considerations
  • THE CONCLUSION OF SE IS BASED ON THE FINDING THAT PENTACHLOROPHENOL CAN BE CARCINOGENIC UNDER SOME CIRCUMSTANCES, AS WAS THE CASE IN THE STOP-STUDY EXPOSURE OF 1,000 PPM FOR ONE YEAR; HOWEVER UNDER STANDARD CONDITIONS, FOR MALE RATS GIVEN DOSES OF 200, 400, OR 600 PPM IN FEED FOR 2 YEARS, THERE WAS NO EVIDENCE OF CARCINOGENIC ACTIVITY.
Female Rats: No Evidence