National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8518

Target Organs and Levels of Evidence for TR-490

Toxicology and Carcinogenesis Studies of Glutaraldehyde (CASRN 111-30-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Glutaraldehyde
111-30-8
10/30/1998Disinfectant and sterilizing agent. Embalming fluid. Chemical intermediate for adhesives, electrical products, tanning soft leathers (HSDB 1990). In photographic developing, dental materials.Inhalation
R: 0, 250, 500, OR 750 PPB; 50/SEX/GROUP M: 0, 62.5, 125, OR 250 PPB; 50/SEX/ GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: SQUAMOUS EPITHELIUM HYPERPLASIA; SQUAMOUS EPITHELIUM INFLAMMATION;RESPIRATORY EPITHELIUM HYPERPLASIA; RESPIRATORY EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM GOBLET CELL HYPERPLASIA; OLFACTORY EPITHELIUM HYALINE DEGENERATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: SQUAMOUS EPITHELIUM HYPERPLASIA; SQUAMOUS EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM HYPERPLASIA; RESPIRATORY EPITHELIUM INFLAMMATION; RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM GOBLET CELL HYPERPLASIA; OLFACTORY EPITHELIUM HYALINE DEGENERATION
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: RESPIRATORY EPITHELIUM SQUAMOUS METAPLASIA; RESPIRATORY EPITHELIUM; HYALINE DEGENERATION; INFLAMMATION


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