National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14832

Target Organs and Levels of Evidence for TR-492

Toxicology and Carcinogenesis Studies of Gallium Arsenide (CASRN 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Gallium arsenide
1303-00-0
Semiconductors. Magnetoresistance devices. Light-emitting diodes. Microwave generation. Inhalation
R&M:0,0.1,1,10,37,75 MG/M3/20 & 10 PER GROUP RESPECTIVELY
Battelle Northwest Laboratory

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Gallium arsenide
1303-00-0
05/21/1999Semiconductors. Magnetoresistance devices. Light-emitting diodes. Microwave generation. Inhalation
R: 0, 0.01, 0.1, OR 1.0 MG/M3; 50/SEX/GROUP M: 0, 0.1, 0.5, OR 1.0 MG/M3; 50/SEX/GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: ATYPICAL HYPERPLASIA; EPITHELIAL HYPERPLASIA; CHRONIC INFLAMMATION; PROTEINOSIS; EPITHELIAL METAPLASIA
  • LARYNX: HYPERPLASIA; CHRONIC INFLAMMATION; SQUAMOUS METAPLASIA; EPIGLOTTIS HYPERPLASIA
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 2/50 7/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/50 2/50 3/50 COMBINED 0/50 0/50 4/50 9/50
  • Adrenal Gland Medulla: BENIGN PHEOCHROMOCYTOMA 4/50 5/49 6/50 13/49
  • Hematopoietic System: MONONUCLEAR CELL LEUKEMIA 22/50 21/50 18/50 33/50
Non-Neoplastic Lesions
  • LUNG: ATYPICAL HYPERPLASIA; CHRONIC INFLAMMATION; PROTEINOSIS; EPITHELIAL METAPLASIA
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: SUPPURATIVE INFLAMMATION; CHRONIC INFLAMMATION; HISTIOCYTIC CELL INFILTRATION; EPITHELIAL HYPERPLASIA; PROTEINOSIS
  • LYMPH NODE: (TRACHEOBRONCHIAL) HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: SUPPURATIVE INFLAMMATION; CHRONIC INFLAMMATION; HISTIOCYTIC CELL INFILTRATION; EPITHELIAL HYPERPLASIA; PROTEINOSIS
  • LYMPH NODE: (TRACHEOBRONCHIAL) HYPERPLASIA


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