National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14840

Target Organs and Levels of Evidence for TR-496

Toxicology and Carcinogenesis Studies of Fumonisin B1 (CASRN 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Fumonisin B1
116355-83-0
05/21/1999Mycotoxin produced by certain strains of fusarium moniliforme, a commonly occurring fungi on U.S. agricultural products, especially corn. No known usesDosed-Feed
R&M: 0, 5, 15, 50, 100, OR 150 PPM
National Center for Toxicological Research

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/48 0/40 0/48 2/48 5/48 OR CARCINOMA 0/48 0/40 0/48 7/48 10/48 COMBINED 0/48 0/40 0/48 9/48 15/48
Non-Neoplastic Lesions
  • KIDNEY: TUBULAR CELL EPITHELIAL HYPERPLASIA
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: HYPERTROPHY
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 5/47 3/48 1/48 16/47 31/45 OR CARCINOMA 0/47 0/48 0/48 10/47 9/45 COMBINED 5/47 3/48 1/48 19/47 39/45
Non-Neoplastic Lesions
  • LIVER: HYPERTROPHY; APOPTOSIS


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