National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14842

Target Organs and Levels of Evidence for TR-497

Toxicology and Carcinogenesis Studies of Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Methacrylonitrile
126-98-7
05/03/2001Homo- and co-polymers, elastomers, coatings and plastics. Chemical intermediate. Replacement for acrylonitrile in certain uses. (NTP executive summary). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
RATS: 0, 3, 10, OR 30 MG/KG MICE: 0, 1.5, 3, OR 6 MG/KG; 50/SEX/DOSE/SPECIES
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; METAPLASIA
  • LIVER: CYTOPLASMIC VACUOLIZATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; METAPLASIA
  • LIVER: CYTOPLASMIC VACUOLIZATION
Male Mice: No Evidence
Female Mice: No Evidence


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