Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/14842

Target Organs and Levels of Evidence for TR-497

Toxicology and Carcinogenesis Studies of Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Methacrylonitrile
126-98-7
05/03/2001Homo- and co-polymers, elastomers, coatings and plastics. Chemical intermediate. Replacement for acrylonitrile in certain uses. (NTP executive summary). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
RATS: 0, 3, 10, OR 30 MG/KG MICE: 0, 1.5, 3, OR 6 MG/KG; 50/SEX/DOSE/SPECIES
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; METAPLASIA
  • LIVER: CYTOPLASMIC VACUOLIZATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • NASAL CAVITY: (OLFACTORY EPITHELIUM) ATROPHY; METAPLASIA
  • LIVER: CYTOPLASMIC VACUOLIZATION
Male Mice: No Evidence
Female Mice: No Evidence