Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/14850

Target Organs and Levels of Evidence for TR-501

Toxicology and Carcinogenesis Studies of p,p'-Dichlorodiphenyl Sulfone (CASRN 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
p,p'-Dichlorodiphenyl sulfone
80-07-9
05/18/2000Starting material in production of plasticsDosed-Feed
MR: 0, 10, 30, OR 100 PPM; FR & MICE: 0, 30, 100, OR 300 PPM; 50/SEX/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY; BILE DUCT HYPERPLASIA; CENTRILOBULAR DEGENERATION
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LIVER: CENTRILOBULAR HYPERTROPHY; EOSINOPHILIC FOCUS