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Target Organs and Levels of Evidence for TR-502

Toxicology and Carcinogenesis Studies of Chloral Hydrate (CASRN 302-17-0) in B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Chloral hydrate
05/18/2000Medication: CNS depressant & sedative agent; in liniments; used in pediatrics; intermediate in plastics, pesticides. Also found in drinking water as result of chlorination.Gavage
0, 25, 50, OR 100 MG/KG
National Center for Toxicological Research

Levels of Evidence

Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Pituitary Gland: (PARS DISTALIS) ADENOMA 0/45 2/44 0/47 5/41 (REGIMEN A)
  • Pituitary Gland: (PARS DISTALIS) ADENOMA 0/45 3/36 1/36 1/33 5/41 (REGIMEN B)