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Target Organs and Levels of Evidence for TR-506

Toxicology and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Acrylonitrile
107-13-1
05/03/2001Chem. Intermediate for antioxidants, pharmaceuticals, dyes, surface-active agents. Monomer in organic synthesis. Pesticide fumigant for grain. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
MICE: 0, 2.5, 10, OR 20 MG/KG; 50/SEX/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 3/50 4/50 19/50 25/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 8/50 9/50 COMBINED 3/50 4/50 26/50 32/50
  • Harderian Gland: ADENOMA 5/50 16/50 24/50 27/50 ADENOMA OR CARCINOMA 6/50 16/50 27/50 30/50
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA; HYPERKERATOSIS
  • HARDERIAN GLAND: HYPERPLASIA
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 3/50 6/50 24/50 19/50 SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 11/50 COMBINED 3/50 7/50 25/50 29/50
  • Harderian Gland: ADENOMA 10/50 10/50 25/50 23/50 ADENOMA OR CARCINOMA 11/50 10/50 26/50 25/50
May Have Been Related
  • Ovary: BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/50 4/50 1/50
  • Lung: ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 6/50 6/50 14/50 9/50
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA
  • OVARY: ATROPHY