National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6404

Target Organs and Levels of Evidence for TR-509

Toxicology and Carcinogenesis Studies of 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83-6; 11% cis,trans Isomer in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2,4-Hexadienal
142-83-6
10/18/2001Food additive and chemical intermediate. Naturally occurring in a variety of plant products. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0, 22.5, 45, OR 90 MG/KG M: 0, 30, 60, OR 120 MG/KG
Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 3/50 10/50 29/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 3/50 11/50 29/50
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA
Female Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 17/50
Non-Neoplastic Lesions
  • FORESTOMACH: EPITHELIAL HYPERPLASIA
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 4/50 5/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 0/50 2/50 COMBINED 2/50 4/50 5/50 10/50
May Have Been Related
  • Oral Cavity: (TONGUE) SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 2/50
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS EPITHELIAL HYPERPLASIA
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 2/49 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/49 0/50 7/50 COMBINED 2/50 2/49 11/50 18/50
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS EPITHELIAL HYPERPLASIA


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.