National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6414

Target Organs and Levels of Evidence for TR-514

Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
trans-Cinnamaldehyde
14371-10-9
09/05/2002Naturally occurring derivative of cinnamon bark, a flavoring. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Microencapsulation in Feed
0 (UNTREATED), 0 (VEHICLE), 1,000, 2,100, or 4,100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%)
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
trans-Cinnamaldehyde
14371-10-9
09/05/2002Naturally occurring derivative of cinnamon bark, a flavoring. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Microencapsulation in Feed
R&M: 0 (UNTREATED), 0 (VEHICLE), 1,000, 2,100, or 4,100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%)
Battelle Columbus Laboratory

Levels of Evidence

Male Mice: No Evidence
Female Mice: No Evidence


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