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Target Organs and Levels of Evidence for TR-518

Toxicology and Carcinogenesis Studies of Triethanolamine (CASRN 102-71-6) in B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Triethanolamine
102-71-6
05/22/2003Intermediate in manufacture surfactants, textile specialties, waxes, polishes, herbicides, petroleum demulsifiers, toilet goods, cement additives, cutting oils, in making mineral & vegetable oil emulsions, solvent, pharmaceutic aid (alkalizer) (Merck 1989). Is widely used as an ingredient in emulsifiers, thickeners, wetting agents, detergents, and alkalinizing agents in cosmetic products; as a chemical intermediate for anionic and nonionic surfactants and surface active agents in household cleaning agents, textiles, herbicides, pharmaceutical ointments, and other products; as a vulcanization accelerator in the manufacture of rubber; and in many other industrial applications.Topical Application
MM: 0, 200, 630, OR 2000 MG/KG; FM: 0, 100, 300, OR 1000 MG/KG
Battelle Columbus Laboratory

Levels of Evidence

Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Liver: HEMANGIOSARCOMA 1/50 0/50 6/50 1/50
Non-Neoplastic Lesions
  • LIVER: EOSINOPHILIC FOCUS
  • SKIN: (EPIDERMAL) HYPERPLASIA; SUPPURATIVE INFLAMMATION; ULCER; (DERMAL) CHRONIC INFLAMMATION
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 9/50 18/50 20/50 33/50 COMBINED 12/50 23/50 24/50 34/50
Non-Neoplastic Lesions
  • LIVER: EOSINOPHILIC FOCUS
  • SKIN: (EPIDERMAL) HYPERPLASIA; SUPPURATIVE INFLAMMATION; ULCER; (DERMAL) CHRONIC INFLAMMATION