Target Organs and Levels of Evidence for TR-520

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) 57465-28-8	02/17/2004	Gavage FEMALE RATS ONLY: PCB-126 -- 0, 10, 30, 100, 175, 300, 550, OR 1000 NG/KG; 100/DOSE	Battelle Columbus Laboratory

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: CHOLANGIOCARCINOMA 0/53 0/55 1/53 0/53 5/53 6/51 22/53 2/50 OR ADENOMA 1/53 2/55 1/53 0/53 2/53 4/51 7/53 0/50 OR HEPATOCHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 0/51 3/53 0/50 Lung: CYSTIC KERATINIZING EPITHELIOMA 0/53 0/55 0/53 0/53 1/53 11/51 35/51 0/50 OR SQUAMOUS CELL CARCINOMA 0/53 0/55 0/53 0/53 0/53 1/51 2/51 0/50 Oral Cavity: GINGIVAL SQUAMOUS CELL CARINOMA (ORAL MUCOSA) 0/53 1/55 1/53 1/53 2/53 2/53 7/53 2/50
May Have Been Related	Adrenal Gland Cortex: ADENOMA OR CARCINOMA 0/52 2/55 1/53 0/53 1/53 1/52 4/53 3/50 Liver: CHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 1/51 1/53 0/50
Non-Neoplastic Lesions	LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; DIFFUSE FATTY CHANGE; BILE DUCT HYPERPLASIA; BILE DUCT CYST; OVAL CELL HYPERPLASIA; NECROSIS; PIGMENTATION; INFLAMMATION; NODULAR HYPERPLASIA; PORTAL FIBROSIS; CHOLANGIOFIBROSIS; TOXIC HEPATOPATHY LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA ADRENAL CORTEX: ATROPHY; CYTOPLASMIC VACUOLIZATION PANCREAS: CHRONIC ACTIVE INFLAMMATION; ACINAR ATROPHY; ACINAR CYTOPLASMIC VACUOLIZATION; ARTERIAL CHRONIC ACTIVE INFLAMMATION KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY HEART: CARDIOMYOPATHY THYROID GLAND: FOLLICULAR CELL HYPERTROPHY THYMUS: ATROPHY; SEVERITY OF ATROPHY SPLEEN: LYMPHOID FOLLICULAR ATROPHY CLITORAL GLAND: CYSTIC DUCT MESENTERY: ARTERIAL CHRONIC ACTIVE INFLAMMATION