https://ntp.niehs.nih.gov/go/18965

Target Organs and Levels of Evidence for TR-523

Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Diisopropylcarbodiimide
693-13-0		 09/28/2005 Topical Application
R&M: 0, 10, 20, OR 40 MG/KG; 50/SEX/SPECIES		 Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • BRAIN: HEMORRHAGE; NEURONAL NECROSIS; FIBRINOID ARTERIOLE NECROSIS
  • LUNG: HEMORRHAGE
  • SKIN: EPIDERMAL HYPERPLASIA; CHRONIC INFLAMMATION
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION; ALVEOLAR EPITHELIAL HYPERPLASIA
  • SKIN: EPIDERMAL HYPERPLASIA; CHRONIC INFLAMMATION
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPIDERMAL HYPERPLASIA; DERMAL FOCAL INFLAMMATION
Female Mice: No Evidence
 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Diisopropylcarbodiimide
693-13-0		 09/28/2005 Topical Application
R: 0, 10, 20, 40, 80, OR 160 MG/KG M: 0, 17.5, 35, 70, 140, OR 280 10 SEX/SPECIES/GROUP, 6 GROUPS		 BioReliance, Inc

Levels of Evidence: None