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Target Organs and Levels of Evidence for TR-523

Toxicology and Carcinogenesis Studies of Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Diisopropylcarbodiimide
693-13-0
09/28/2005As a peptide coupling reagent; as a condensing reagent in dipeptide synthesis; in preparation of polyimide precursor coatings for electrophoretic image display fabrication; as a military nerve agent stabilizer.Topical Application
R&M: 0, 10, 20, OR 40 MG/KG; 50/SEX/SPECIES
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • BRAIN: HEMORRHAGE; NEURONAL NECROSIS; FIBRINOID ARTERIOLE NECROSIS
  • LUNG: HEMORRHAGE
  • SKIN: EPIDERMAL HYPERPLASIA; CHRONIC INFLAMMATION
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • LUNG: CHRONIC INFLAMMATION; ALVEOLAR EPITHELIAL HYPERPLASIA
  • SKIN: EPIDERMAL HYPERPLASIA; CHRONIC INFLAMMATION
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • SKIN: EPIDERMAL HYPERPLASIA; DERMAL FOCAL INFLAMMATION
Female Mice: No Evidence


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Diisopropylcarbodiimide
693-13-0
09/28/2005As a peptide coupling reagent; as a condensing reagent in dipeptide synthesis; in preparation of polyimide precursor coatings for electrophoretic image display fabrication; as a military nerve agent stabilizer.Topical Application
R: 0, 10, 20, 40, 80, OR 160 MG/KG M: 0, 17.5, 35, 70, 140, OR 280 10 SEX/SPECIES/GROUP, 6 GROUPS
BioReliance, Inc

Levels of Evidence