National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9830

Target Organs and Levels of Evidence for TR-525

Toxicology and Carcinogenesis Studies of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4) in Female Harlan Sprague-Dawley Rats (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
TEF evaluation (PECDF (Pentachlorodibenzofuran))
57117-31-4
02/17/2004One of 5 dioxin-like compounds plus 2 mixtures being tested to determine if the (TEFs) for these chemicals would be predictive of rodent carcinogenicity. Ambient human exposure to DLCs occurs through the ingestion of foods containing residues of DLCs that bioconcentrate through the food chain. The main sources of PeCDF releases into the environment are from combustion and incineration sources.Gavage
FEMALE RATS ONLY: PeCDF -- 0, 6, 20, 44, 92, OR 200 NG/KG; 100/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/53 0/53 1/53 0/52 2/53 4/53 1/50 OR CHOLANGIOCARCINOMA 0/53 0/53 0/53 1/52 1/53 2/53 0/50
  • Oral Cavity: (ORAL MUCOSA) GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 2/53 1/53 0/53 1/53 3/53 3/50
May Have Been Related
  • Lung: CYSTIC KERATINIZING EPITHELIOMA (MULTIPLE) 0/53 0/53 0/53 0/53 0/53 1/52 0/50
  • Pancreas Acinar Cell: ADENOMA OR CARCINOMA 0/53 0/53 0/53 0/52 2/52 0/52 2/49
  • Uterus/Cervix: CARCINOMA 1/53 1/53 0/53 1/53 5/53 2/53 1/50
Non-Neoplastic Lesions
  • LIVER: HEPATOCYTE HYPERTROPHY; MULTINUCLEATED HEPATOCYTE; OVAL CELL HYPERPLASIA; DIFFUSE FATTY CHANGE; PIGMENTATION; NODULAR HYPERPLASIA; EOSINOPHILIC FOCUS; NECROSIS; BILE DUCT HYPERPLASIA; BILE DUCT FIBROSIS; TOXIC HEPATOPATHY; CHOLANGIOFIBROSIS
  • ORAL MUCOSA: GINGIVAL SQUAMOUS HYPERPLASIA
  • UTERUS: ENDOMETRIAL CYSTIC HYPERPLASIA; CHRONIC ACTIVE INFLAMMATION; SQUAMOUS METAPLASIA
  • LUNG: ALVEOLAR EPITHELIUM, METAPLASIA, BRONCHIOLAR; SQUAMOUS METAPLASIA
  • PANCREAS: ACINAR CYTOPLASMIC VACUOLIZATION; ARTERIAL CHRONIC ACTIVE INFLAMMATION
  • THYROID GLAND: FOLLICULAR CELL HYPERTROPHY
  • THYMUS: ATROPHY; SEVERITY OF ATROPHY
  • ADRENAL CORTEX: CYSTIC DEGENERATION
  • KIDNEY: NEPHROPATHY; SEVERITY OF NEPHROPATHY
  • HEART: CARDIOMYOPATHY
  • FORESTOMACH: SQUAMOUS HYPERPLASIA


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