National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/LOE-TR-536

Target Organs and Levels of Evidence for TR-536

Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy)methane (CAS No. 111-91-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
bis(2-Chloroethoxy)methane
111-91-1
11/19/2009Used as a starting compound to produce polysulfide elastomers. Also used as a solventTopical Application
R: 0, 75, 150, OR 300 MG/KG; MM: 0, 150, 300 OR 600 MG/KG; FM: 0, 100, 200, OR 400 MG/KG
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Olfactory epithelium, degeneration
  • Forestomach: Inflammation; ulcer
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Olfactory epithelium, degeneration
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Heart: Cardiomyopathy; myocardium, fibrosis; infiltration cellular, mononuclear cell; vacuolization cytoplasmic
  • Forestomach: Ulcer
  • Skin: Dermis, fibrosis, inflammation; epidermis, hyperplasia
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Heart: Cardiomyopathy; myocardium, infiltration cellular, mononuclear cell; vacuolization cytoplasmic


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