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https://ntp.niehs.nih.gov/go/LOE-TR-541

Target Organs and Levels of Evidence for TR-541

Toxicology and Carcinogenesis Studies of Formamide (CASRN 75-12-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Formamide
75-12-7
05/16/2007Solvent, softener, intermediate in organic synthesis; water-soluble ink formulations. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R&M: 0, 10, 20, 40, 80, OR 160 MG/KG; 10/SEX/SPECIES/DOSE
Battelle Columbus Laboratory

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Formamide
75-12-7
05/16/2007Solvent, softener, intermediate in organic synthesis; water-soluble ink formulations. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R&M: 0, 20, 40, OR 80 MG/KG; 50/SEX/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Bone Marrow: hyperplasia
Female Rats: No Evidence
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hemangiosarcoma (1/50, 5/50, 7/50, 8/50)
Non-Neoplastic Lesions
  • Testes: mineralization of artery; mineralization of tunic
  • Spleen: hematopoietic cell proliferation
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Liver: adenoma or carcinoma 9/50, 15/50, 13/50, 18/50