National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/LOE-TR-542

Target Organs and Levels of Evidence for TR-542

Toxicology and Carcinogenesis Studies of Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Cumene
98-82-8
05/16/2007Used in the production of phenol, acetone, and alpha-methylstyrene; solvent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R: 0, 250, 500, OR 1000 PPM MM: 0, 250, 500, OR 1000 PPM FM: 0, 125, 250, OR 500 PPM 50/SEX/SPECIES
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50)
  • Kidney Tubular Cell: renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50)
May Have Been Related
  • Testis: interstitial cell adenoma
Non-Neoplastic Lesions
  • Nasal Cavity: olfactory epithelium, hyperplasia; basal cell; respiratory epithelium, hyperplasia
  • Kidney: tubule, hyperplasia; papilla, mineralization; pelvis, transitional epithelium, hyperplasia
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Nasal Cavity: respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50)
Non-Neoplastic Lesions
  • Nasal Cavity: olfactory epithelium, hyperplasia; basal cell; respiratory epithelium, hyperplasia
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50)
May Have Been Related
  • Spleen: hemangioscaroma
  • Thyroid Gland Follicular Cell: adenoma
Non-Neoplastic Lesions
  • Lung: alveolar epithelium, bronchiole, metaplasia; bronchiole, hyperplasia
  • Nasal Cavity: olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, hyperplasia, atypical; olfactory epithelium, glands, hyperplasia; inflammation, suppurative
  • Liver: eosinophilic focus
  • Forestomach: epithelium, hyperplasia; ulcer; inflammation
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50)
  • Liver: adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50)
Non-Neoplastic Lesions
  • Lung: alveolar epithelium, bronchiole, metaplasia; bronchiole, hyperplasia
  • Nasal Cavity: olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, hyperplasia, atypical; olfactory epithelium, glands, hyperplasia; respiratory epithelium, metaplasia, squamous; inflammation, suppurative


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