National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/LOE-TR-544

Target Organs and Levels of Evidence for TR-544

Toxicology and Carcinogenesis Studies of Dibromoacetonitrile (CASRN 3252-43-5) in F344/N Rats and B6C3F1 Mice (Drinking Water studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Water disinfection byproducts (Dibromoacetonitrile)
3252-43-5
02/27/2008Formed as a result of the reaction of chlorine oxidizing compounds (e.g., chlorine gas, hypochlorous acid, and hypochlorite) with natural organic matter, particularly nitrogen-containing organic compounds, in water containing bromine; it is also a by-product of ozone disinfection.Dosed-Water
R&M: 0, 50 100, OR 200 MG/L; 50 SEX/SPECIES/DOSE
Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Oral Cavity: Squamous cell papilloma or carcinoma 0/50 0/50 2/50 5/50
  • Glandular Stomach: Adenoma 0/50 0/50 0/50 2/50
Non-Neoplastic Lesions
  • Esophagus: Epithelial hyperkeratosis
Female Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Oral Cavity: Squamous cell papilloma 1/50 0/50 4/50 0/50
May Have Been Related
  • Skin: Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 0/50 0/50 3/50 4/50
Non-Neoplastic Lesions
  • Esophagus: Epithelial hyperkeratosis
  • Glandular Stomach: Glandular ectasia
  • Tongue: Squamous epithelial hyperplasia
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: Squamous cell papilloma or carcinoma 0/50 1/50 0/50 5/50
May Have Been Related
  • Liver: Hepatoblastoma 1/50 7/50 3/50 2/50 adenoma, carcinoma or hepatoblastoma 37/50 46/50 43/50 42/50
Non-Neoplastic Lesions
  • Forestomach: Squamous epithelial hyperplasia
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: Squamous cell papilloma 1/50 0/50 5/50 14/50


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