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https://ntp.niehs.nih.gov/go/28810

Endocrine disruptor (Genistein): Target Organs and Levels of Evidence TR-545

Toxicology and Carcinogenesis Study of Genistein (CASRN 446-72-0) in Sprague-Dawley Rats (feed study)

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Endocrine disruptor (Genistein)
446-72-0
06/12/2006 Antineoplastic agent; growth inhibitor; naturally-occurring phytoestrogen found in several plants including soy products. Nutritional and pharmaceutical applications. Dosed-Feed:
concentration in feed 0, 5, 100, 500 PPM
National Center for Toxicological Research

Levels of Evidence

Male Rats (F1C): No Evidence


Female Rats (F1C): Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: ADENOMA OR ADENOCARCINOMA 9/54 4/50 8/50 16/49
  • Pituitary Gland: ADENOMA OR CARCINOMA 38/54 40/50 34/50 46/49
Other Considerations
  • Mammary Gland: FIBROADENOMA 32/54 27/50 28/50 12/49


Male Rats (F1T140): No Evidence


Female Rats (F1T140):Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Pituitary Gland: ADENOMA OR CARCINOMA 38/54 32/49 40/50 44/50


Male Rats (F3T21): No Evidence


Female Rats (F3T21):Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Mammary Gland: ADENOMA OR ADENOCARCINOMA 7/53 8/49 11/50 13/50