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https://ntp.niehs.nih.gov/go/LOE-TR-549

Target Organs and Levels of Evidence for TR-549

Toxicology and Carcinogenesis Studies of Bromochloroacetic acid (CASRN 5589-96-8) in F344/N Rats and B6C3F1 Mice (Drinking water studies)

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Water disinfection byproducts (Bromochloroacetic acid)
5589-96-8
02/27/2008 EPA water chemical; byproduct of water chlorination Dosed-Water
R&M: 0, 250, 500, or 1000 mg/l; 50/sex/species/dose
Southern Research Institute

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Mesothelium (Abdominal Cavity/Tunica Vaginalis): Malignant Mesothelioma 1/50 5/50 10/50 6/50
  • Intestines: (Large): Adenoma 0/50 2/50 0/50 4/50
May Have Been Related
  • Liver: Adenoma 2/50 0/50 3/50 4/50
  • Pancreas Islet Cell: Adenoma 3/50 4/50 9/50 3/50
Non-Neoplastic Lesions
  • Liver: Eosinophilic focus
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Intestines: (Large): Adenoma 0/50 0/50 3/50 7/50
  • Mammary Gland: Fibroadenoma, multiple 22/50 24/50 43/50 38/50
May Have Been Related
  • Liver: Adenoma 0/50 0/50 0/50 3/50
Non-Neoplastic Lesions
  • Liver: Eosinophilic focus; mixed cell focus
  • Lung: Alveolar epithelium hyperplasia
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Adenoma 27/50 40/50 40/50 31/50 carcinoma 19/50 25/50 36/50 45/50 adenoma or carcinoma 34/50 44/50 49/50 49/50 hepatoblastoma 4/50 11/50 28/50 34/50
Non-Neoplastic Lesions
  • Liver: Hepatocyte cytoplasmic vacuolization; centrilobular necrosis
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Adenoma 27/50 48/50 44/50 46/50 carcinoma 14/50 23/50 26/50 20/50 adenoma or carcinoma 31/50 49/50 46/50 46/50
Non-Neoplastic Lesions
  • Liver: Hepatocyte cytoplasmic vacuolization; eosinophilic focus