National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/LOE-TR-554

Target Organs and Levels of Evidence for TR-554

Toxicology and Carcinogenesis Studies of 5-(Hydroxymethyl)-2-furfural (CASRN 67-47-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
5-(Hydroxymethyl)-2-furfural
67-47-0
02/27/2008A decomposition product of carbohydrates and is formed during cooking or heat sterilization of food. It has been identified in a wide variety of heat processed foods including milk, fruit juices, spirits, honey, etc. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R&M: 0, 188, 375, OR 750 MG/KG; 50/SEX/SPECIES/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Olfactory epithelium, degeneration; respiratory metaplasia; respiratory epithelium, metaplasia, squamous
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Olfactory epithelium, degeneration; respiratory metaplasia; respiratory epithelium, metaplasia, squamous; inflammation, suppurative; nasolacrimal duct, inflammation, chronic
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Olfactory epithelium, metaplasia, degeneration, hyaline droplet accumulation, inflammation, chronic active; glands, inflammation, chronic active; hyperplasia, dilatation; respiratory epithelium, hyaline droplet accumulation
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: Adenoma 14/50 26/49 26/50 6/50
Non-Neoplastic Lesions
  • Nasal Cavity: Olfactory epithelium, metaplasia, degeneration, hyaline droplet accumulation, inflammation, chronic active; glands, inflammation, chronic active; hyperplasia, dilatation; respiratory epithelium, hyaline droplet accumulation


Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
5-(Hydroxymethyl)-2-furfural
67-47-0
02/27/2008A decomposition product of carbohydrates and is formed during cooking or heat sterilization of food. It has been identified in a wide variety of heat processed foods including milk, fruit juices, spirits, honey, etc. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0, 94, 188, 375, 750 OR 1500 MG/KG; M: 0, 47, 94, 188, 375, OR 750 MG/KG
Battelle Columbus Laboratory

Levels of Evidence



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