https://ntp.niehs.nih.gov/go/34035

Target Organs and Levels of Evidence for TR-555

Toxicology and Carcinogenesis Studies of 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
1,2-Dibromo-2,4-dicyanobutane
35691-65-7		 02/27/2008 Topical Application
R&M: 0, 0.2, 0.6, 2, 6, OR 18 MG/KG, 5X PER WEEK; 10/SEX/DOSE		 BioReliance, Inc

Levels of Evidence: None

 
Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
1,2-Dibromo-2,4-dicyanobutane
35691-65-7		 02/27/2008 Topical Application
R: 0, 2, 6, OR 18 MG/KG AND M: 0, 0.6, 2, OR 6 MG/KG; 50/SEX/SPECIES/D0SE		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Epidermis, hyperplasia and hyperkeratosis; dermis, inflammation
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Epidermis, hyperplasia, hyperkeratosis and necrosis; dermis, inflammation
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Epidermis, hyperplasia
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Epidermis, hyperplasia; dermis, chronic active inflammation