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Target Organs and Levels of Evidence for TR-555

Toxicology and Carcinogenesis Studies of 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2-Dibromo-2,4-dicyanobutane
35691-65-7
02/27/2008As a preservative in paints, emulsions, dispersed pigments, adhesives, joint cements, metalworking fluids, paper, inks, waxes, household products, and cosmetics. As a biocide protects water-based systems from bacteria, fungi, yeast and algae. (exec sum)Topical Application
R&M: 0, 0.2, 0.6, 2, 6, OR 18 MG/KG, 5X PER WEEK; 10/SEX/DOSE
BioReliance, Inc

Levels of Evidence



Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
1,2-Dibromo-2,4-dicyanobutane
35691-65-7
02/27/2008As a preservative in paints, emulsions, dispersed pigments, adhesives, joint cements, metalworking fluids, paper, inks, waxes, household products, and cosmetics. As a biocide protects water-based systems from bacteria, fungi, yeast and algae. (exec sum)Topical Application
R: 0, 2, 6, OR 18 MG/KG AND M: 0, 0.6, 2, OR 6 MG/KG; 50/SEX/SPECIES/D0SE
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Epidermis, hyperplasia and hyperkeratosis; dermis, inflammation
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Epidermis, hyperplasia, hyperkeratosis and necrosis; dermis, inflammation
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Epidermis, hyperplasia
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Epidermis, hyperplasia; dermis, chronic active inflammation