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https://ntp.niehs.nih.gov/go/LOE-TR-566

Target Organs and Levels of Evidence for TR-566

Toxicology and Carcinogenesis Studies of Diethylamine (CASRN 109-89-7) in F344/N Rats and B6C3F1 Mice (Inhalation studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Diethylamine
109-89-7
11/19/2009Used in the production of the corrosion inhibitor n,n-diethylethanolamine, and in the production of some pesticides and insect repellents, pharmaceuticals and rubber processing chemicals (Executive Summary). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R: 0, 31, 62.5, OR 125 PPM M: 0, 16, 31, OR 62.5 PPM; 50/SEX/SPECIES/DOSE
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; goblet cell, hyperplasia; inflammation, suppurative; olfactory epithelium, accumulation, hyaline droplet; olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; respiratory epithelium, ulcer; turbinate, necrosis
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; goblet cell, hyperplasia; inflammation, suppurative; olfactory epithelium, accumulation, hyaline droplet; olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; respiratory epithelium, ulcer; turbinate, necrosis
  • Pleura: Inflammation, chronic
  • Lung: Alveolus, infiltration cellular, histiocyte; inflammation, chronic
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; glands, respiratory epithelium, hyperplasia; inflammation, suppurative; olfactory epithelium, atrophy; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, metaplasia, squamous; turbinate, hyperostosis
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: Glands, respiratory epithelium, accumulation, hyaline droplet; glands, respiratory epithelium, inflammation, chronic active; glands, respiratory epithelium, hyperplasia; inflammation, suppurative; olfactory epithelium, atrophy; olfactory epithelium, respiratory metaplasia; respiratory epithelium, accumulation, hyaline droplet; respiratory epithelium, metaplasia, squamous; respiratory epithelium, necrosis; turbinate, hyperostosis