https://ntp.niehs.nih.gov/go/37118

Target Organs and Levels of Evidence for TR-572

Toxicology and Carcinogenesis Studies of Methyl trans-Styryl Ketone (CASRN 1896-62-4) in F344/N Rats and B6C3F1 Mice (Feed and Dermal Studies)

Chemical (Study Title)
CASRN		 Peer Review Date Route/Exposure Levels Study Laboratory
Methyl trans-styryl ketone
1896-62-4		 01/26/2011 Topical Application
R&M: 0, 10, 30, or 90 mg/kg; 50/sex/species/dose		 Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis; site of application, inflammation, chronic; site of application, hyperplasia, melanocyte
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis; site of application, inflammation, chronic; site of application, hyperplasia, melanocyte