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https://ntp.niehs.nih.gov/go/37118

Target Organs and Levels of Evidence for TR-572

Toxicology and Carcinogenesis Studies of Methyl trans-Styryl Ketone (CASRN 1896-62-4) in F344/N Rats and B6C3F1 Mice (Feed and Dermal Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Methyl trans-styryl ketone
1896-62-4
01/26/2011Reactive carbonyl compound used in organic synthetic reactions such as intermediate in organic synthesis, electroplating chemical; pharmaceutical intermediate, biochemical reagent, agricultural chemical intermediate, proposed sunscreen intermediate. Used as flavoring and fragrance additive. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Topical Application
R&M: 0, 10, 30, or 90 mg/kg; 50/sex/species/dose
Southern Research Institute

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis; site of application, inflammation, chronic; site of application, hyperplasia, melanocyte
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin: Site of application, epidermis, hyperplasia; site of application, hyperkeratosis; site of application, inflammation, chronic; site of application, hyperplasia, melanocyte