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Target Organs and Levels of Evidence for TR-574

Toxicology and Carcinogenesis Studies of Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1 Mice (Topical Application Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Pyrogallol
87-66-1
02/08/2012Naturally occurring in food. Used as a modifier in oxidation dyes including hair dyes & colors. also used as developer in photography; a mordant for dying wool; a reagent for antimony & bismuth; and as a reducer for gold, silver & mercury salts. Used for process engraving & for making colloidal solutions of metals. Used in the manufacture of pharmaceuticals & pesticides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Topical Application
R&M: 0, 5, 20, OR 75 MG/KG; 50/SEX/SPECIES/DOSE
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin (site of application): hyperplasia; hyperkeratosis; inflammation; sebaceous gland, hyperplasia
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin (site of application): hyperplasia; hyperkeratosis; inflammation; sebaceous gland, hyperplasia
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Skin: (site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 2/50
Non-Neoplastic Lesions
  • Skin (site of application): hyperplasia; hyperkeratosis; inflammation; fibrosis; pigmentation; sebaceous gland, hyperplasia; ulcer
  • Skin: hyperplasia; hyperkeratosis; ulcer; inflammation; fibrosis
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Skin: (site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 4/50
Non-Neoplastic Lesions
  • Skin (site of application): hyperplasia; hyperkeratosis; inflammation; fibrosis; pigmentation; sebaceous gland, hyperplasia; ulcer
  • Skin: hyperplasia; hyperkeratosis; ulcer; inflammation; fibrosis; sebaceous gland, hyperplasia
  • Mammary gland: hyperplasia