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Target Organs and Levels of Evidence for TR-576

Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (CASRN 15625-89-5) in F344/N Rats (Topical Application Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Trimethylolpropane triacrylate
15625-89-5
02/08/2012Used in the production of ultraviolet-curable inks, electron beam irradiation-curable coatings, & polymers & resins; as a component of photopolymer & flexographic printing plates & photoresists; & as an ingredient in acrylic glues & anaerobic sealants. Also used in paper & wood impregnates, wire & cable extrusion, polymer-impregnated concrete, & polymer concrete structural composites.Topical Application
R&M: 0, 0.3, 1.0, OR 3.0 MG/KG; 65/SEX/SPECIES/DOSE
Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Malignant Mesothelioma: 0/50, 2/50, 2/50, 5/50
Non-Neoplastic Lesions
  • Skin (site of application): epidermis, hyperplasia; hyperkeratosis
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin (site of application): epidermis, hyperplasia; hyperkeratosis
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hepatoblastoma 0/50, 4/50, 0/50, 3/50; hepatocholangiocarcinoma 0/50, 0/50, 1/50, 2/50
  • Uterus: stromal polyp or stromal sarcoma 0/50, 1/50, 2/50, 6/50
Non-Neoplastic Lesions
  • Skin (site of application): epidermis, hyperplasia; hyperplasia, melanocyte; inflammation, chronic