https://ntp.niehs.nih.gov/go/LOE-TR-583

Target Organs and Levels of Evidence for TR-583

Toxicology Studies of Bromodichloroacetic Acid (CASRN 71133-14-7) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Bromodichloroacetic Acid in F344/NTac Rats and B6C3F1/N Mice (Drinking Water Studies)

Chemical
CASRN
(Study Title)		 Peer Review Date Route/Exposure Levels Study Laboratory
Water disinfection byproducts (Bromodichloroacetic acid)
71133-14-7		 05/22/2014 Dosed-Water
R&M: 0, 250, 500, or 1000 mg/L; 50/sex/species/dose		 Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • All Organs: malignant mesothelioma 1/50 12/50 18/50 37/50
  • Skin: squamous cell papilloma, keratoacanthoma, sebaceous gland adenoma, basal cell adenoma, basal cell carcinoma, or squamous cell carcinoma 9/50 7/50 15/50 21/50
  • Skin: (subcutaneous tissue): fibroma 4/50 6/50 10/50 15/50
May Have Been Related
  • Brain: glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 4/50 3/50
  • Oral Cavity: (oral mucosa and tongue): squamous cell papilloma or squamous cell carcinoma 1/50 0/50 3/50 3/50
Non-Neoplastic Lesions
  • Bone marrow: angiectasis; hyperplasia
  • Liver: eosinophilic focus
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: fibroadenoma 28/50 47/50 47/50 39/50 carcinoma 0/50 1/50 3/50 8/50 fibroadenoma, adenoma, or carcinoma 28/50 47/50 48/50 42/50
May Have Been Related
  • Brain: glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 3/50 1/50
Non-Neoplastic Lesions
  • Bone marrow: angiectasis; hyperplasia
  • Liver: hematopoietic cell proliferation; eosinophilic focus
  • Spleen: hematopoietic cell proliferation
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hepatocellular carcinoma 12/50 22/50 27/49 39/51 hepatoblastoma 4/50 24/50 40/49 34/51
  • Harderian Gland: adenoma 6/50 11/50 14/49 19/51 adenoma or carcinoma 6/50 11/50 14/49 20/51
Non-Neoplastic Lesions
  • Liver: focus of cellular alteration, atypical
  • Testis: atrophy
  • Epididymis: atrophy; hypospermia; epithelium, degeneration
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hepatocellular adenoma 33/49 42/50 42/49 44/50 hepatocellular carcinoma 9/49 17/50 22/49 26/50 hepatoblastoma 0/49 1/50 4/49 6/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/49 44/50 43/49 46/50
Non-Neoplastic Lesions
  • Liver: eosinophilic focus; focus of cellular alteration, atypical