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https://ntp.niehs.nih.gov/go/727751

Target Organs and Levels of Evidence for TR-585

Toxicology Studies of Green Tea Extract (CASRN GREENTEAEXTR) in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Green Tea Extract in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)

Chemical
CASRN
(Study Title)
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Green tea extract
GREENTEAEXTR
05/22/2014 Extract of green tea used as dietary supplement Gavage
R: 0, 100, 300, or 1,000 mg/kg; M: 0, 30, 100, or 300 mg/kg; 50/sex/species/dose
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Liver: necrosis
  • Stomach, glandular: mucosa necrosis
  • Small intestine, duodenum: mucosa, necrosis
  • Small intestine, ileum: mucosa necrosis
  • Small intestine, jejunum: mucosa necrosis
  • Small intestine, (duodenum, ileum, jejunum): necrosis
  • Nasal Cavity: suppurative inflammation; lamina propria, mineralization; lamina propria, pigmentation; nasopharyngeal duct, suppurative inflammation; nerve, atrophy; olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, necrosis; olfactory epithelium, pigmentation; respiratory epithelium, atrophy; respiratory epithelium, metaplasia, squamous; turbinate, deformity; turbinate, hyperostosis
  • Lung: suppurative inflammation
  • Heart (epicardium): inflammation
  • Spleen: lymphoid depletion
Female Rats: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Liver: necrosis; oval cell hyperplasia
  • Stomach, glandular: mucosa necrosis
  • Small intestine, duodenum: mucosa, necrosis
  • Small intestine, ileum: mucosa necrosis
  • Small intestine, jejunum: mucosa necrosis
  • Small intestine, (duodenum, ileum, jejunum): necrosis
  • Nose: foreign body; suppurative inflammation; epithelium, nasopharyngeal duct, necrosis; epithelium, nasopharyngeal duct, regeneration; lamina propria, mineralization; lamina propria, pigmentation; nasopharyngeal duct, suppurative inflammation; nerve, atrophy; olfactory epithelium, atrophy; olfactory epithelium, hyperplasia, basal cell; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, necrosis; olfactory epithelium, pigmentation; respiratory epithelium, atrophy; respiratory epithelium, necrosis; respiratory epithelium, pigmentation; turbinate, deformity; turbinate, hyperostosis
  • Lung: suppurative inflammation
  • Heart (epicardium): inflammation
  • Bone marrow: hyperplasia
  • Spleen: lymphoid depletion
Male Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Liver: hematopoietic cell proliferation; inflammation
  • Nasal Cavity: foreign body; hyperostosis; suppurative inflammation; nasopharyngeal duct, degeneration; nerve, atrophy; olfactory epithelium, atrophy; olfactory epithelium, fibrosis; olfactory epithelium, metaplasia, respiratory; respiratory epithelium, metaplasia, squamous; respiratory epithelium, hyperplasia; respiratory epithelium, necrosis; septum, perforation; turbínate, atrophy
  • Mandibular lymph node: lymphoid hyperplasia; plasma cell infiltration
  • Bone marrow: hyperplasia
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Nasal Cavity: foreign body; hyperostosis; suppurative inflammation; nerve, atrophy; olfactory epithelium atrophy; olfactory epithelium, fibrosis; olfactory epithelium, metaplasia, respiratory; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; respiratory epithelium, necrosis; septum, perforation; turbinate, atrophy
  • Mandibular lymph node: lymphoid hyperplasia; plasma cell infiltration
  • Bone marrow: hyperplasia