Target Organs and Levels of Evidence for TR-586
Toxicology and Carcinogenesis Studies of CIMSTAR 3800 (CASRN CIMSTAR3800) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)
Chemical
CASRN
(Study Title) |
Peer Review Date |
Primary Uses |
Route/Exposure Levels |
Study Laboratory |
Metal working fluids (CIMSTAR 3800)
CIMSTAR3800 |
05/22/2014 |
Semisynthetic; metalworking fluid |
Inhalation
R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose |
Battelle Northwest Laboratory |
Levels of Evidence
Male Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Prostate Gland: adenoma 1/50 1/50 1/50 3/50 adenoma or carcinoma 1/50 1/50 2/50 3/50
|
| Non-Neoplastic Lesions |
- Nasal Cavity: goblet cell, hyperplasia; glands, olfactory epithelium, hyperplasia; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet
- Larynx: metaplasia, squamous
- Lung: inflammation, lymphohistiocytic; bronchus-associated lymphoid tissue, hyperplasia, lymphohistiocytic; alveolar epithelium, hyperplasia
- Lymph node, bronchial: hyperplasia, lymphohistiocytic
- Lymph node, mediastinal: hyperplasia, lymphohistiocytic
|
Female Rats: Equivocal Evidence
| Type |
Organ/Tissue (Lesion) |
| May Have Been Related |
- Skin: squamous cell papilloma or keratoacanthoma 0/50 0/50 0/50 4/50
- Uterus: adenocarcinoma or mixed malignant Müllerian tumor (original and residual longitudinal evaluation combined) 1/50 4/50 5/50 6/50
|
| Non-Neoplastic Lesions |
- Nose: goblet cell, hyperplasia; glands, olfactory epithelium, hyperplasia; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet
- Larynx: metaplasia, squamous
- Lung: inflammation, lymphohistiocytic; bronchus-associated lymphoid tissue, hyperplasia, lymphohistiocytic
- Lymph node, bronchial: hyperplasia, lymphohistiocytic
- Lymph node, mediastinal: hyperplasia, lymphohistiocytic
|
Male Mice: No Evidence
| Type |
Organ/Tissue (Lesion) |
| Non-Neoplastic Lesions |
- Lung: bronchiole, hyperplasia; alveolar epithelium, hyperplasia; infiltration cellular, histiocyte
- Nasal Cavity: olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, atrophy; inflammation, chronic active
- Larynx: metaplasia, squamous; inflammation, chronic active
|
Female Mice: Some Evidence
| Type |
Organ/Tissue (Lesion) |
| Neoplastic Lesions |
- Thyroid Gland: follicular cell carcinoma 0/50 0/48 0/50 3/50
- Lung: alveolar/bronchiolar carcinoma 4/50 1/50 4/50 8/50 alveolar/bronchiolar adenoma or carcinoma 4/50 5/50 6/50 12/50
|
| Non-Neoplastic Lesions |
- Thyroid gland: follicular cell, hyperplasia
- Lung: bronchiole, hyperplasia; alveolar epithelium, hyperplasia; infiltration cellular, histiocyte; perivascular, inflammation, chronic active
- Nasal Cavity: olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; olfactory epithelium, metaplasia, respiratory
- Larynx: metaplasia, squamous; inflammation, chronic active
|
