https://ntp.niehs.nih.gov/go/727777
Target Organs and Levels of Evidence for TR-586
Toxicology and Carcinogenesis Studies of CIMSTAR 3800 (CASRN CIMSTAR3800) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)
Chemical
CASRN
(Study Title)
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Peer Review Date
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Primary Uses
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Route/Exposure Levels
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Study Laboratory
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Metal working fluids (CIMSTAR 3800)
CIMSTAR3800
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05/22/2014
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Semisynthetic; metalworking fluid
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Inhalation
R&M: 0, 10, 30, or 100 mg/m3; 50/sex/species/dose
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Battelle Northwest Laboratory
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Levels of Evidence
Male Rats: Equivocal Evidence
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Type
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Organ/Tissue (Lesion)
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May Have Been Related
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-
Prostate Gland: adenoma 1/50 1/50 1/50 3/50 adenoma or carcinoma 1/50 1/50 2/50 3/50
|
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Non-Neoplastic Lesions
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-
Nasal Cavity: goblet cell, hyperplasia; glands, olfactory epithelium, hyperplasia; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet
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Larynx: metaplasia, squamous
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Lung: inflammation, lymphohistiocytic; bronchus-associated lymphoid tissue, hyperplasia, lymphohistiocytic; alveolar epithelium, hyperplasia
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Lymph node, bronchial: hyperplasia, lymphohistiocytic
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Lymph node, mediastinal: hyperplasia, lymphohistiocytic
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Female Rats: Equivocal Evidence
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Type
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Organ/Tissue (Lesion)
|
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May Have Been Related
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-
Skin: squamous cell papilloma or keratoacanthoma 0/50 0/50 0/50 4/50
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Uterus: adenocarcinoma or mixed malignant Müllerian tumor (original and residual longitudinal evaluation combined) 1/50 4/50 5/50 6/50
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Non-Neoplastic Lesions
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-
Nose: goblet cell, hyperplasia; glands, olfactory epithelium, hyperplasia; olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet
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Larynx: metaplasia, squamous
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Lung: inflammation, lymphohistiocytic; bronchus-associated lymphoid tissue, hyperplasia, lymphohistiocytic
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Lymph node, bronchial: hyperplasia, lymphohistiocytic
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Lymph node, mediastinal: hyperplasia, lymphohistiocytic
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Male Mice: No Evidence
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Type
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Organ/Tissue (Lesion)
|
|
Non-Neoplastic Lesions
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-
Lung: bronchiole, hyperplasia; alveolar epithelium, hyperplasia; infiltration cellular, histiocyte
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Nasal Cavity: olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; olfactory epithelium, metaplasia, respiratory; olfactory epithelium, atrophy; inflammation, chronic active
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Larynx: metaplasia, squamous; inflammation, chronic active
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Female Mice: Some Evidence
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Type
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Organ/Tissue (Lesion)
|
|
Neoplastic Lesions
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-
Thyroid Gland: follicular cell carcinoma 0/50 0/48 0/50 3/50
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Lung: alveolar/bronchiolar carcinoma 4/50 1/50 4/50 8/50 alveolar/bronchiolar adenoma or carcinoma 4/50 5/50 6/50 12/50
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Non-Neoplastic Lesions
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-
Thyroid gland: follicular cell, hyperplasia
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Lung: bronchiole, hyperplasia; alveolar epithelium, hyperplasia; infiltration cellular, histiocyte; perivascular, inflammation, chronic active
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Nasal Cavity: olfactory epithelium, accumulation, hyaline droplet; respiratory epithelium, accumulation, hyaline droplet; olfactory epithelium, metaplasia, respiratory
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Larynx: metaplasia, squamous; inflammation, chronic active
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