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Target Organs and Levels of Evidence for TR-587

Toxicology and Carcinogenesis Studies of Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats and B6C3F1/N Mice (Gavage Studies)

Chemical
CASRN
(Study Title)
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Tetrabromobisphenol A
79-94-7
10/29/2013 Flame retardant for plastics, paper, and textiles. Gavage
R&M: 0, 250, 500, or 1000 mg/kg; 50/sex/species/dose
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Testis: interstitial cell, adenoma 0/50 0/50 1/50 3/50
Female Rats: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Uterus: adenoma (original transverse review) 0/50 0/50 3/50 4/50 adenocarcinoma (original transverse review) 3/50 3/50 8/50 9/50 (original transverse and residual longitudinal reviews, combined) 4/50 10/50 15/50 16/50 malignant mixed Müllerian tumor (original transverse review) 0/50 4/50 0/50 2/50 adenoma, adenocarcinoma, or malignant mixed Müllerian tumor (original transverse review) 3/50 7/50 11/50 13/50 (original transverse and residual longitudinal reviews, combined) 6/50 11/50 16/50 19/50
Non-Neoplastic Lesions
  • Uterus: endometrium, hyperplasia, atypical (residual longitudinal review)
  • Ovary: rete ovarii cyst
Male Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Liver: hepatoblastoma 2/50 11/50 8/50
May Have Been Related
  • Intestines (Large): (Cecum or Colon) adenoma or carcinoma 0/50 0/50 3/50
  • All Organs: (Hemangiosarcoma) 1/50 5/50 8/50
Non-Neoplastic Lesions
  • Liver: clear cell focus; eosinophilic focus
  • Kidney: renal tubule, cytoplasmic alteration
  • Forestomach: ulcer; infiltration cellular, mononuclear cell; inflammation; epithelium, hyperplasia
Female Mice: No Evidence
Type Organ/Tissue (Lesion)
Non-Neoplastic Lesions
  • Forestomach: ulcer; infiltration cellular, mononuclear cell; inflammation; epithelium, hyperplasia