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Target Organs and Levels of Evidence for TR-590

TR-590 Toxicology and Carcinogenesis Studies of Antimony Trioxide (CASRN 1309-64-4) in Wistar Han Rats and B6C3F1 Mice (Inhalation Studies)

Chemical
CASRN
(Study Title)
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Antimony Trioxide
1309-64-4
02/16/2016 Flame retardant in fabrics, resins, wood coatings; pigment & opacifier in glass, ceramics & plastic; chemical intermediate for potassium antimony tartrate; raw material on manufacture of antimony metal. Inhalation
R&M: 0, 3, 10, or 30 mg/m3; 50/sex/species/concentration
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar adenoma (3/50, 4/50, 6/50, 8/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 4/50, 8/50, 8/50)
  • Adrenal Gland Medulla: benign pheochromocytoma (1/49, 0/50, 2/49, 7/50)
Non-Neoplastic Lesions
  • Lung: foreign body; inflammation, chronic active; alveolus, inflammation, suppurative; perivascular, infiltration cellular, lymphocyte; proteinosis; alveolar epithelium, hyperplasia; bronchiole, epithelium, hyperplasia; fibrosis
  • Adrenal medulla: hyperplasia
  • Nasal Cavity: foreign body; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous
  • Larynx: foreign body
  • Trachea: foreign body
  • Bone marrow: hyperplasia
  • Lymph node, bronchial: foreign body; hyperplasia, lymphoid; pigmentation
  • Lymph node, mediastinal: foreign body; hyperplasia, lymphoid
  • Mediastinum: artery, inflammation, chronic active
  • Pancreas: artery, inflammation, chronic active
  • Mesentery: artery, inflammation, chronic active
  • Lung: artery, inflammation, chronic active
  • Kidney: renal tubule, accumulation, hyaline droplet; artery, inflammation, chronic active
  • Artery (all tissues combined): inflammation, chronic active
  • Eye: ciliary body, inflammation, acute
Female Rats: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar adenoma (0/50, 2/50, 6/50, 5/50)
  • Adrenal Gland Medulla: benign pheochromocytoma (0/49, 2/49, 2/49, 6/50); benign or malignant pheochromocytoma (0/49, 2/49, 2/49, 7/50)
May Have Been Related
  • Lung: cystic keratinizing epithelioma or squamous cell carcinoma (0/50, 0/50, 0/50, 3/50)
Non-Neoplastic Lesions
  • Lung: foreign body; inflammation, chronic active; alveolus, inflammation,; perivascular, infiltration cellular, lymphocyte ; proteinosis; alveolar epithelium, hyperplasia; bronchiole, epithelium, hyperplasia; alveolar epithelium, metaplasia, squamous; fibrosis
  • Adrenal medulla: hyperplasia
  • Nasal Cavity: foreign body; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous
  • Larynx: foreign body; inflammation, chronic active
  • Trachea: foreign body
  • Bone marrow: hyperplasia
  • Lymph node, bronchial: foreign body; hyperplasia, lymphoid
  • Lymph node, mediastinal: foreign body; hyperplasia, lymphoid
  • Mediastinum: artery, inflammation, chronic active
  • Pancreas: artery, inflammation, chronic active; artery, necrosis
  • Mesentery: artery, inflammation, chronic active
  • Lung: artery, inflammation, chronic active
  • Kidney: renal tubule, accumulation, hyaline droplet; nephropathy; artery, inflammation, chronic active
  • Artery (all tissues combined): inflammation, chronic active
  • Eye: retina, atrophy; ciliary body, inflammation, acute
Male Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar carcinoma (4/50, 18/50, 20/50, 27/50)
  • Skin: fibrous histiocytoma (0/50, 1/50, 1/50, 4/50); fibrous histiocytoma or fibrosarcoma (0/50, 1/50, 3/50, 4/50)
Non-Neoplastic Lesions
  • Lung: infiltration cellular, lymphocyte; foreign body; inflammation, chronic active; alveolus, fibrosis; pluera, fibrosis; pleura, inflammation; alveolar epithelium, hyperplasia; bronchiole, epithelium, hyperplasia
  • Bone marrow: hyperplasia
  • Thymus: depletion cellular
  • Nasal Cavity: foreign body; respiratory epithelium, inflammation, chronic active
  • Larynx: foreign body; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; squamous epithelium, hyperplasia
  • Trachea: foreign body; epithelium, hyperplasia
  • Lymph node, bronchial: hyperplasia, lymphoid; foreign body; infiltration cellular, histiocyte
  • Lymph node, mediastinal: hyperplasia, lymphoid; foreign body; infiltration cellular, histiocyte
  • Heart: epicardium, inflammation, chronic active
  • Stomach, forestomach: inflammation, chronic active
Female Mice: Clear Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Lung: alveolar/bronchiolar adenoma (1/50, 10/50, 19/50, 8/50); alveolar/bronchiolar carcinoma (2/50, 14/50, 11/50, 11/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 22/50, 27/50, 18/50)
  • All Organs: malignant lymphoma (7/50, 17/50, 20/50, 27/50)
May Have Been Related
  • Skin: squamous cell carcinoma (0/50, 0/50, 0/50, 2/50)
Non-Neoplastic Lesions
  • Lung: infiltration cellular, lymphocyte; foreign body; inflammation, chronic active; alveolus, fibrosis; pluera, fibrosis; pleura, inflammation; alveolar epithelium, hyperplasia; bronchiole, epithelium, hyperplasia
  • Spleen: hematopoietic cell proliferation
  • Bone marrow: hyperplasia
  • Thymus: depletion cellular
  • Nasal Cavity: foreign body; respiratory epithelium, metaplasia, squamous
  • Larynx: foreign body; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; squamous epithelium, hyperplasia
  • Trachea: foreign body
  • Lymph node, bronchial: hyperplasia, lymphoid; foreign body; infiltration cellular, histiocyte
  • Lymph node, mediastinal: hyperplasia, lymphoid; foreign body; infiltration cellular, histiocyte
  • Heart: epicardium, inflammation, chronic active